Treatment satisfaction and insulin analogues

Hypoglycemia frequency and treatment satisfaction in patients receiving insulin analogues for treatment of type 1 diabetes mellitus

Paulo Dornelles Picon 2,4 https://orcid.org/0000-0002-5803-9405

Gabriela Berlanda 1,2 https://orcid.org/0000-0003-0188-8198

Gabriela H. Telo 3 https://orcid.org/0000-0001-9093-383X

Bárbara Côrrea Krug 4 https://orcid.org/0000-0003-4556-3555

Rafael Selbach Scheffel 1,2 https://orcid.org/0000-0002-8858-309X

Bruna Pasinato 5 https://orcid.org/0000-0001-6051-7894

Fernando Iorra 5 https://orcid.org/0000-0002-6503-9323

João Gabbardo dos Reis 6 https://orcid.org/0000-0003-2353-1448

Beatriz D. Schaan 1,2 https://orcid.org/0000-0002-2128-8387

Arch Endocrinol Metab. 2021;65/2

ABSTRACT

Objective: The aim of this study was to evaluate the frequency of hypoglycemia and the treatment satisfaction in patients with type 1 diabetes (T1D) using insulin analogues.

Subjects and methods: This observational retrospective study included 516 adult patients with T1D from 38 cities in Southern Brazil. Demographics and clinical data were collected using a self-report questionnaire. Hypoglycemia was defined as an event based on either symptoms or self-monitored blood glucose < 70 mg/dL. Treatment satisfaction was evaluated using the Diabetes Treatment Satisfaction Questionnaire status version (DTSQs) and with a specific question with scores ranging from 0–10. Common mental disorders were assessed using the General Health Questionnaire (GHQ-12).

Results: Overall, the mean age was 38 ± 14 years and 52% of the participants were women. The median diabetes duration was 18 years. The scores for insulin analogue treatment satisfaction were higher than those for previous treatments. DTSQ scores had a median value of 32 (interquartile range 29–35) and remained unchanged over time. The percentage of patients with hypoglycemia (including severe and nocturnal) was comparable across groups divided according to duration of use of insulin analogues. Most patients (n=395, 77%) screened positive for common mental disorders. Conclusions: Patient satisfaction with insulin analogue treatment was high and remained unchanged with time. Episodes of hypoglycemia also remained unchanged over time among patients using insulin analogues.

1 Programa de Pós-Graduação em Endocrinologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil 2 Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil 3 Departamento de Medicina Interna, Escola de Medicina da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brasil 4 Secretaria Estadual da Saúde do Rio Grande do Sul, Porto Alegre, RS, Brasil 5 Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil 6 Coordenação Executiva do Comitê de Contingência de Combate ao COVID-19 do Governo do Estado de São Paulo, SP, Brasil

Correspondence to: Gabriela Berlanda Centro de Pesquisa Clínica, Hospital de Clínicas de Porto Alegre Rua Ramiro Barcelos, 2350 90035-903 – Porto Alegre, RS, Brasil gabrielaberlanda@yahoo.com.br Received on July/9/2020 Accepted on Nov/20/2020 DOI: 10.20945/2359-3997000000332

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